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Monday, October 12, 2026Closing data · 4:00 PM ET
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XBI

SPDR S&P Biotech ETFState Street · S&P Biotechnology Select Industry · Since 2006 · Thematic
Previous close
151.40
Change
−1.54%
Expense ratio
0.35%
AUM
$10.4B
Holdings
165
14% look-through
YTD
+24.2%
1Y
+44.2%
5Y
+21.0%

Price history

Daily close1M6M1Y5Y
1201401601802026-042026-052026-072026-082026-10

Returns

Price return, excluding dividends
1M3MYTD1Y3Y5Y
XBI−3.1%−2.5%+24.2%+44.2%+117.5%+21.0%
SPY+1.8%+3.9%+14.1%+19.2%+80.3%+74.5%
Difference−4.9%−6.4%+10.1%+25.1%+37.2%−53.5%

Top 25 holdings

Holdings as of 2026-10-09, from the issuer's daily holdings fileSource file
TickerCompanyWeight1D ChgFinDog View
—TWIST BIOSCIENCE CORPNot covered1.87%—
—NATERA INCNot covered1.78%—
—IOVANCE BIOTHERAPEUTICS INCNot covered1.64%—
—UNITED THERAPEUTICS CORPNot covered1.59%—
—HALOZYME THERAPEUTICS INCNot covered1.51%—
—EXELIXIS INCNot covered1.51%—
—TG THERAPEUTICS INCNot covered1.49%—
—PROTAGONIST THERAPEUTICS INCNot covered1.45%—
—SPYRE THERAPEUTICS INCNot covered1.45%—
—CRISPR THERAPEUTICS AGNot covered1.44%—
—VAXCYTE INCNot covered1.41%—
—PTC THERAPEUTICS INCNot covered1.41%—
—KRYSTAL BIOTECH INCNot covered1.40%—
—GRAIL INCNot covered1.37%—
—NEUROCRINE BIOSCIENCES INCNot covered1.35%—
—REVOLUTION MEDICINES INCNot covered1.34%—
—ERASCA INCNot covered1.34%—

Look-through checkup

Valuation, growth and FinDog views of the holdings, weighted by position; covers 14% of the fund
Holdings P/E ?
27.3
Weighted harmonic mean; loss-makers excluded
Holdings forward P/E ?
18.1
Position-weighted
5-year valuation percentile
50
Where each company's P/E sits in its own 5-year range, weighted
Revenue growth (YoY)
+14.9%
Position-weighted
Gross margin
70.9%
Position-weighted
Holdings dividend yield
1.36%
Position-weighted

Earnings season

Results reported by the holdings over the past 75 days, weighted by positionSeason
Reported
13%
91% of look-through weight
EPS beat
76%
of reported weight
EPS miss
24%
of reported weight
Guidance raised
0.0%
Guidance cut
0.0%
Top holdings that have reported